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Wiki Article
16
Jun
2009
Drug Combinations
Posted By: Bluebelly  |  Comments ( 0 )

People combine drugs for a range of reasons including:
  • Potentiation of pleasurable effects
  • To mitigate the unpleasurable effects of another drug
  • To achieve separate but simultaneous effects.

While combining particular drugs can prove to be a pleasurable experience for people, in some instances it can be highly dangerous. It should also be stated that different people will respond differently to different drugs and drug combinations, and the same person can have a different response on different occasions.
The table below provides a summary of some known drug combinations and possible implications.



Amphetamine Type Substance

Combined with

Equals

Amphetamines

Adderall

Can increase the risk of heatstroke, hypertension, heart attack and death. This combination may also increase the risk of brain (nerve) damage.

Alcohol

Can increase blood pressure, and heart rate, increasing risk of heart attack.

ARV (Antiretrovirals)

Can increase toxicity leading to fatality

Atropine

Can lead to increased body temperature and disturbances of heart rhythm

Cocaine

Risk of heatstroke, hypertension, heart attack and death. This combination may also increase the risk of brain (nerve) damage.

GHB

Amphetamine can allow a much larger dose of GHB to be consumed, however as the dose of amphetamine subsides an overdose of GHB can occur.

MAOI Anti-depressants

Can result in severe hypertensive crisis (very high blood pressure)

MDMA

Risk of heatstroke, hypertension, heart attack and death. This combination may also increase the risk of brain (nerve) damage.

MDMA

Amphetamines

Risk of heatstroke, hypertension, heart attack and death. This combination may also increase the risk of brain (nerve) damage.

Alcohol

There have been some unexplained deaths associated with mixing alcohol and MDMA. This combination can produce bizarre behavior, and memory loss. Alcohol can also compound dehydration and make your comedown last longer.

Antihistamines

May enhance or interfere with MDMA effect.

ARV (Antiretrovirals)

Can increase toxicity leading to fatality

Atropine

Can lead to increased body temperature and disturbances of heart rhythm

Birth control medications

MDMA can cause vomiting and nausea which may cause you to vomit up birth control medication.

Cannabis

A small amount of cannabis used prior to taking MDMA may reduce nausea and anxiety.

Cocaine

Cocaine competes with MDMA and can actually blunt the effect of MDMA, however there have been a number of deaths attributed to combining cocaine and MDMA.

Caffeine
Ephedra
Pseudoephedrine

Can increase risk of heart attack, stroke and heatstroke.

DXM (Dextromethorphan)

This is a dangerous combination that interferes with perception of body heat and can contribute to brain (nerve) damage.

GHB

MDMA can allow a much larger dose of GHB to be consumed, however as the dose of MDMA subsides an overdose of GHB can occur. Mixing GHB and alcohol is also a particularly dangerous combination that can lead to overdose and death.

Heroin and other opiates

MDMA's effects may mask opiate effects of heroin and make overdose easier

LSD

Taken simultaneously can produce a stronger effect of both drugs.

MAOI Anti-depressants

Can result in severe hypertensive crisis (high blood pressure) or ‘serotonin syndrome’

Psilocybin (mushrooms)

Taken simultaneously can produce a stronger effect of both drugs.

SSRI Anti depressants(Prozac, Zoloft)

SSRI’s taken prior to MDMA may reduce the effect of MDMA. Use of MDMA prior to taking SSRI’s however can lead to brain (nerve) damage.

Viagra

Can cause priapism (where penis remains erect after sexual stimulation ceases) which can be very painful and can cause permanent damage to your penis.

Cocaine

Alcohol

Can mask depressant effects of alcohol. Can increase blood pressure, tension and jitters. The body converts the broken-down products of alcohol and cocaine into cocaethylene, a chemical more deadly than cocaine, which increases the risk of overdose.

See Talk to Frank's fact sheet here for more information on cocaethylene.


Amphetamines

Risk of heatstroke, hypertension, heart attack and death. This combination may also increase the risk of brain (nerve) damage.

ARV (Antiretrovirals)

Can cause increased liver-toxicity and overdose.

Heroin or opiates

Increased risk of disturbed heart rhythm and possible heart failure. Cocaine will mitigate possible overdose effects of heroin while active, however the cocaine will wear off more quickly than the heroin leaving the user vulnerable to heroin overdose.


MAOI Anti-depressants

Can result in severe hypertensive crisis


MDMA

Cocaine competes with MDMA and can actually blunt the effect of MDMA, however there have been a number of deaths attributed to combining cocaine and MDMA.

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